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Eli Lilly and Company Oligonucleotide Scientist SMDD and RNA Therapeutics CMC - R-5301 in Indianapolis, Indiana

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. Were looking for people who are determined to make life better for people around the world.Synthetic Molecule Design and Development (SMDD) and theRNA Therapeutics Area (TA) areinnovation-focused organizations within Lilly Research Laboratories striving to identify, develop and apply cutting-edge technologies to deliver maximum benefit to our patients. The RNA TA endeavors to operate as a small, agile and autonomous biotech-like company within the walls of a much larger company and works collaboratively with SMDD to efficiently deliver the RNAi clinical portfolio. Our team is looking for a creative and energetic chemist with experience in chemistry, manufacturing and control (CMC) of oligonucleotides to participate in the process design, development, and manufacture of RNAi targets.Expertise should include knowledge of monomer synthesis methods and oligonucleotide solid phase synthesis methods. Additionally, knowledge of novel synthetic alternatives as well as understanding of purification, isolation and formulation aspects are attractive attributes of top candidates. The chemist hired into this role will collaborate with a growing team comprised of process chemists, analysts, and engineers aimed at development and optimization of existing methods and the exploration of novel approaches to oligonucleotide synthesis. We strive to broadly improve oligonucleotide synthesis, including reagents, synthesis mode, analysis methods, yield, quality, and environmental footprint. This role is intended to operate at the interface between the RNA TA and SMDD with responsibilities for developing oligonucleotide synthesis capabilities while supporting activities to enable GMP manufacture of RNAi targets in support of clinical trials. Developing and working with external contract manufacturing organizations (CMOs) to support oligonucleotide synthesis and development will be an important aspect of this role.Top candidates for this position will be expected to:Bring oligonucleotide development experience to SMDD and foster growth in the teams capabilities in the area of oligonucleotide process chemistry.Identify and lead scientific projects/process improvements where solutions are developed through interactions with diverse talent across the larger organization.Possess fluent knowledge in modern synthetic organic and nucleic acid chemistry methods with the drive to challenge existing methods.Demonstrate high learning agility regarding grasping and exploiting new scientific concepts and methods across multiple disciplines; strong skills related to automated reactor platforms and purification technologies; be able to apply these learnings to a rapidly evolving portfolio of RNAi assets.Provide examples of novel contributions to chemical design and mechanism-based problem solving as part of project driven goals such as total synthesis, novel methodology development and oligonucleotide synthesis. These examples should also be reflected in a strong publication record in peer reviewed journals.Collaborate with internal and external manufacturing partners to develop robust chemical processes that are readily amenable to efficient drug substance manufacturing for both clinical and commercial settings.Engage the external chemistry environment through presentations, publication at external symposia or consortia. These activities are expected to advance the internal Lilly portfolio and help create new opportunities.Identify, partner and develop external chemistry innovations to complement existing int

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