Lilly Principal Research Scientist in Indianapolis, Indiana
The scientists in the department of PK/PD & Pharmacometrics at Lilly are the leaders in research and development throughout the value chain from preclinical lead molecule identification to clinical post-drug approval with the goal of identifying and developing the right drug with the right dose for the right patient and living the model-informed paradigm of drug research and development. Our organization is looking for a dynamic and experienced scientist who will be responsible for :
Developing and implementing Pharmacometrics and Quantitative System Pharmacology modeling and simulation strategies to address key questions and influence portfolio decisions, including, but not limited to the application of drug-disease models, literature models, quantitative risk/benefit decision tools, quantitative systems pharmacology models and trial-design optimization analytics.
Leading the development of novel QSP platform(s) for various disease states and improving existing QSP platforms.
Anticipating and recognizing the issues affecting the drug discovery/development and finding effective solutions by partnership and collaboration with cross-functional teams to enable decision-making.
Providing scientific leadership in multi-disciplinary project teams to support the selection of the right target, molecule, dose, patient population and development strategies.
Leading and supporting the preparation and delivery of overall program plan, study protocols, model-based analysis plans, data interpretation, reporting and communication of results to stakeholders for right decision-making.
Leading the preparation of relevant sections of INDs, IBs, CTDs and other regulatory documents for development and registration of new drugs and line extensions; interact with regulatory agencies world-wide.
Providing coaching and mentoring to fellow scientists within the group and in other disciplines as well as interact, teach and collaborate with scientists in academia.
Representing the group to increase visibility externally, through key publications, active leadership in key scientific organizations, industry trade groups or consortia.
In summary, in this exciting scientific and technical leadership role you will have opportunities to apply MIDD principle to drug research and development strategies, setting direction for the organization, and drive successful implementation of the strategies to produce results.
Excellent understanding of clinical pharmacology (PK, PD and pharmacometrics) principles.
Proficient in quantitative modeling and simulation software (such as SimBiology, NONMEM, MATLAB, R/S-plus etc.).
Work effectively in a team environment with excellent communication skills.
This position can be located either in Indianapolis, US or Erlwood, UK site.
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Principal Research Scientist-Systems Pharmacology Modeler/Pharmacometrician
PhD and/or MD in relevant scientific field such as biological/pharmaceutical sciences, bioengineering or related field.
At least 5 years experience from industry, regulatory, consulting or academia
Experiences and expertise in quantitative pharmacology modeling is preferred.
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
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